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Pirkey – “Systems Metabolic Engineering of Microorganisms for Chemicals, Fuels and Materials” by Dr. Sang Yup Lee, Korea Advanced Institute of Science and Technology (KAIST)

01/31/2012 @ 3:30 pm - 4:30 pm

Dr. Sang Yup Lee, Korea Advanced Institute of Science and Technology (KAIST)

Dr. Sang Yup Lee, Korea Advanced Institute of Science and Technology (KAIST)2011-2012 Pirkey Lectureship

Seminar Abstract:

Our increasing concerns on limited fossil resources and environmental problems including climate change are urging us to develop sustainable systems for the production of chemicals, fuels and materials from renewable resources. Microorganisms have been and will be playing crucial roles in such bioprocesses. When they are isolated from nature, however, their performance is not good enough to be employed for industrially competitive processes. That is why metabolic engineering is employed to enhance their performance. Metabolic engineering can be defined as purposeful modification of cellular characteristics and performance by employing various tools. Over the last decade, metabolic engineering has become more powerful through the integration with systems biology and synthetic biology. In this lecture, I will present the general strategies for systems metabolic engineering of microorganisms. Several key examples on the production of succinic acid, diamines, butanol, polyesters, and metal nanoparticles by metabolically engineered microorganisms will be presented. It is believed that systems metabolic engineering will be an essential strategy for making any bioprocess competitive. [This work was supported by the Korean Systems Biology Research Grant, Advanced Biomass Research Center, Intelligent Biodesign Research Center, Center for Systems and Synthetic Biotechnology from the Korean Ministry of Education, Science and Technology.]

Sang Yup Lee received B.S. in Chem. E. from Seoul National University in 1986, and Ph.D. in Chem. E. from Northwestern University in 1991. Currently, he is Distinguished Professor and Dean of College of Life Science and Bioengineering at KAIST. He is also the Director of Center for Systems and Synthetic Biotechnology, Director of BioProcess Engineering Research Center, and Director of Bioinformatics Research Center. He has published more than 390 journal papers, and numerous patents. He received many awards, including the National Order of Merit, Citation Classic Award, Elmer Gaden Award, and Merck Metabolic Engineering Award. He is currently Fellow of AAAS, Fellow of American Academy of Microbiology, Fellow of Society for Industrial Microbiology, Fellow of Korean Academy of Science and Technology, Fellow of National Academy of Engineering of Korea, Foreign Associate of National Academy of Engineering USA, Editor-in-Chief of Biotechnology Journal, and editor and board member of many journals. His research interests are metabolic engineering, systems biology and biotechnology, synthetic biology, industrial biotechnology and biorefineries, and nanobiotechnology.

Contact Info:

Sang Yup Lee

Metabolic and Biomolecular Engineering National Research Laboratory

Department of Chemical and Biomolecular Engineering and Department of BioSystems

BioProcess Engineering Research Center and Bioinformatics Research Center

Center for Systems and Synthetic Biotechnology, Institute for the BioCentury

Korea Advanced Institute of Science and Technology (KAIST)

Daejeon 305-701, Korea (leesy@kaist.ac.kr)


3:30 pm - 4:30 pm
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