Research Website

Educational Qualifications

Ph.D., Chemical Engineering, Cornell University (1987)
M.S., Chemical Engineering, Cornell University (1983)
B.Sc., Chemical Engineering, University of Manchester Institute of Science and Technology (UMIST), England (1981)

Courses Taught

CHE 339 Introduction to Biochemical Engineering

Research

1. The discovery, early development and preclinical validation of protein therapeutics for the treatment of cancer, inborn errors of metabolism disorders and other diseases. Our lab has invented and played a key role in the early development of one FDA approved therapeutic protein and four proteins that are currently in clinical trials

2. Molecular level understanding of human antibody immunity. We have developed technologies for determining the identity (sequence), relative abundance and function of the ensemble of circulating antibodies that are elicited as a result of infection, vaccination or in disease states such as cancer and autoimmunity. The application of these technologies is providing important insights that inform vaccine design and aid in the discovery of very potent human therapeutic antibodies.

3. Engineering of the Fc domain of therapeutic antibodies to develop, “second generation” improved therapeutics and to expand our understanding of how antibodies interact with other components of the immune system to help eradicate disease-causing cells.

Awards & Honors

• William H. Walker Award for Excellence in Contributions to Chemical Engineering Literature, American Institute of Chemical Engineering (AIChE), 2019
• National Academy of Inventors, 2015
• American Academy of Arts and Sciences (AAAS), 2015
• Inventor of the Year, University of Texas at Austin, 2014
• Named as one of “Top 20 Translational Researchers,” by Nature Biotechnology, 2014
• Elected to National Academy of Medicine (NAM), 2011
• Named as one of “100 Eminent Chemical Engineers of the Modern Era,” American Institute of Chemical Engineering (AIChE), 2008
• National Academy of Engineering (NAE), 2005
• American Association for the Advancement of Science, 2004
• American Academy of Microbiology, 2004
• Professional Progress Award for Outstanding Progress in Chemical Engineering, American Institute of Chemical Engineering (AIChE), 2003
• Marvin J. Johnson Award in Microbial and Biochemical Technology, American Chemical Society (ACS), 2003
• American Institute for Medical and Biological Engineering (AIMBE), 1996
• Presidential Young Investigator Award, National Science Foundation, 1987

Selected Publications 

• Schommers, P., Kim, D.S…..Georgiou G and F. Klein "Dynamics and Durability of HIV-1 Neutralization are Determined by Viral Replication," Nature Medicine 29: 2763–2774 (2023) PMID: 37957379 doi: 10.1038/s41591-023-02582-3.
• Gjuka D., Adib^, E., Garrison, K, Georgiou, G., Kwiatkowski^, D. J. and E. Stone, “Enzyme-Mediated Depletion of Methylthioadenosine Restores T Cell function in MTAP Deficient Tumors,”  Cancer Cell 41:1774-1787 (2023) PMID: 37774699 doi: 10.1016/j.ccell.2023.09.005.
• Blazeck, J.,  Karamitros, S.K….Stone, E. and G. Georgiou, “Bypassing Evolutionary Dead-ends and Switching the Rate-Limiting Step of a Human Immunotherapeutic Enzyme,” Nature Catalysis 5:952-967 (2022) PMID: 36465553 doi: 10.1038/s41929-022-00856-6.  
• Karamitros, C.S., Murray, K., Winemiller, B., Lamb, C., Stone, E.M., D'Arcy, S., Johnson, K.A., and G. Georgiou, “Leveraging Intrinsic Flexibility to Engineer Enhanced Enzyme Catalytic Activity,” Proc. Natl. Acad. Sci. USA 119:e2118979119 (2022) PMID: 35658075 doi: 10.1073/pnas.2118979119.
• Pataskar, A…..Stone, E., Georgiou G., de Gooijer, M.C., van Tellingen, O., Altelaar, M., Joosten, P.R., Perrakis, A., Olweus, J., Bassani-Sternberg, M., Peeper, D.M. and R. Agami, “Tryptophan Depletion Results in Tryptophan-to-Phenylalanine Substituants,” Nature 603:721-727 (2022) PMID: 35264796 doi: 10.1038/s41586-022-04499-2.
• Jung, J., Mundle, S.T…..G. Georgiou, “High Prevalence of Serum Monoclonal Antibodies to Non-Hemagglutinin Antigens Including Sulfated Glycans in the Elderly after Seasonal Influenza Vaccination,” J. Clinical Investigations 131:e148763 (2021) PMID: 34196304  doi: 10.1172/JCI148763.