Research Website 

Educational Qualifications

Ph.D., Biochemistry, The Ohio State University (2009)

Focus

Antibody repertoires elicited by infection and vaccination, antibody structure and function.

Research

The BCR-Seq and Ig-Seq technologies for high-throughput profiling of antibody repertoires have enabled our team at UT Austin to examine the adaptive immune response at a single molecule level, identifying and quantitating the constituent B-cells and serum antibodies being produced with unparalleled precision. This combined antibody profiling approach provides an invaluable set of metrics to examine the adaptive immune response with high-resolution. Specifically, the ability to resolve the endpoint serum antibody lineages in both health and disease provides a much-needed understanding of the role of humoral immunity in protection and/or pathogenicity in a variety of contexts. To date, we have used Ig-Seq and BCR-seq to delineate antibody repertoires in response to tetanus toxoid, poliomyelitis, influenza, HIV, malaria, dengue virus, and norovirus. More recently, we have extended this approach to patients infected with or vaccinated against SARS-CoV-2.

Publications 

• Voss WN, Mallory MA, Byrne PO, Marchioni JM, Knudson SA, Powers JM, Leist SR, Dadonaite B, Townsend DR, Kain J, Huang Y, Satterwhite E, Castillo IN, Mattocks M, Paresi C, Munt JE, Scobey T, Seeger A, Premkumar L, Bloom JD, Georgiou G, McLellan JS, Baric RS, Lavinder JJ*, Ippolito GC*. Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination. BioRxiv. doi.org/10.1101/2024.01.22.576742. (2024 Jan)
• Voss WN, Hou YJ, Johnson NV, Delidakis G, Kim JE, Javanmardi K, Horton AP, Bartzoka F, Paresi CJ, Tanno Y, Chou C-W, Abbasi SA, Pickens W, George K, Boutz DR, Towers DM, McDaniel JR, Billick D, Goike J, Rowe L, Batra D, Pohl J, Lee J, Gangappa S, Sambhara S, Gadush M, Wang N, Person MD, Iverson BL, Gollihar JD, Dye J, Herbert A, Finkelstein IJ, Baric RS, McLellan JS, Georgiou G, Lavinder JJ*, Ippolito GC*. Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes. Science. 372(6546):1108-1112. doi: 10.1126/science.abg5268. PMID: 33947773. (2021 Jun)
• Lavinder JJ, Horton AP, Georgiou G, Ippolito GC. Next-generation sequencing and protein mass spectrometry for the comprehensive analysis of human cellular and serum antibody repertoires. Curr Opin Chem Biology; 24:112-20. PMID: 25461729. (2015)
• Lavinder JJ*, Wine Y*, Giesecke C, Ippolito GC, Horton AP, Lungu OI, Hoi KH, DeKosky BJ, Murrin EM,
  Wirth MM, Ellington AD, Dorner T, Marcotte EM, Boutz DR, Georgiou G, Identification and characterization of the constituent human serum antibodies elicited by vaccination, Proc. Natl. Acad. Sci. USA; 111: 2259- 2264. (2014)