Maynard, Jennifer Ph.D.
Laurence E. McMakin, Jr. Centennial Faculty Fellow
|Office:||CPE 5.466||Mailing Address:|
|Phone:||(512) 471-9188||The University of Texas at Austin|
|Fax:||(512) 471-7060||Department of Chemical Engineering|
||200 E Dean Keeton St. Stop C0400|
|UT Mail:||C0400||Austin, TX 78712-1589|
Research Areas: Biotechnology
Ph.D., Chemical Engineering, University of Texas at Austin (2002)
B.A., Human Biology, Stanford University (1996)
NIH Postdoctoral Fellow, Microbiology & Immunology, Stanford University (2002-2004)
CHE 317 Material and Energy Balances
CHE 322 Chemical and Engineering Thermodynamics
CHE 363 Mass Transfer and Separations
CHE 379/384/ Bio 337 Quantitative Analysis of Cellular & Molecular Biology
CHE 379 Engineering Global Health
Biotechnology, protein therapeutics, vaccine development, applied immunology and microbiology.
We develop protein therapeutics and vaccines to address unmet medical needs in infectious diseases. These proteins aim to directly interfere in disease progression or augment essential immune system activities. To do this, we design a candidate protein, with an emphasis on engineering the kinetics with which it interacts with other proteins as well as targeting protein transport to specific tissues in the body. This is followed by protein expression and purification to make the protein; biophysical, biochemical and cellular analyses to elucidate the molecular basis of activity; and, ultimately, in vitro and in vivo experiments to evaluate the protein’s ability to prevent disease.
Our specific research goals are to:
- Understand mechanisms of protective immunity and use this information to engineer more effective vaccines and therapeutics.
- Reverse engineer pathogenic strategies used by bacterial pathogens for biomedical and biotechnological applications.
- Control cellular immunity through manipulation of T cell receptor-peptide MHC interactions.
- Apply protein engineering approaches to issues in structural biology.
Awards & Honors
Inaugural University of Texas “Emerging Inventor of the Year” Award (2015)
Bill & Melinda Gates Grand Challenge Awards (2009, 2016)
Texas Exes Teaching Award for the Cockrell School of Engineering (2012)
Most Outstanding Professor in Chemical Engineering, Student Engineering Council (2010)
Packard Fellowship, David and Lucile Packard Foundation (2005)
Dreyfus New Faculty Award (2003)
National Research Service Award, NIH (2002-2004)
- Khan TA, Wang X and Maynard JA. Inclusion of an RGD motif alters invasin-integrin binding specificity. Biochemistry, 55 (14): 2078-90 (2016).
- Nguyen AW, Wagner EK, Laber JR, Goodfield L, Smallridge WE, Padlan EA, Bristol A, Harvill ET, Papin JF, Wolf RF, Kaleko M, Maynard JA. A cocktail of humanized anti-pertussis toxin antibodies limits disease in murine and baboon models of whooping cough. Science Translational Medicine, 7(316): 316ra195 (2015).
- Entzminger KC, Johnson JL, Hyun JM, Lieberman RL, and Maynard JA. Increased Fab thermoresistance via VH-targeted directed evolution. Protein Engineering, Design & Selection, 28(10): 365-77 (2015).
- Wang XZ, Gray MC, Hewlett EL and Maynard JA. The Bordetella adenylate cyclase toxin RTX domain is immunodominant and elicits neutralizing antibodies. J Biological Chemistry 290(6): 3576-91 (2015).
- Seedah EA, Frye Z and Maynard JA. Immunotherapeutic approaches to prevent CMV-mediated disease. ASM Microbiol Spectrum 2(1) 1-12 (2014).
- Wang, ZX, Coljee, VW and Maynard, JA. Back to the future: recombinant polyclonal antibody therapeutics. Current Opinion in Chemical Engineering, 2 (4): 405-415 (2013).
- Entzminger, KC, Chang, C, Myhre RO, McCallum K and, Maynard JA. The Skp chaperone helps fold soluble proteins in vitro by inhibiting aggregation. Biochemistry, 51: 4822-4834 (2012).
- Johnston KP, Maynard JA, Truskett, TM, Borwankar AU, Miller MA, Wilson BK, Dinen AK, Khan TA and Kaczorowski KJ. Concentrated dispersions of equilibrium protein nanoclusters that reversibly dissociate into active monomers. ACS Nano, 6(2): 1357-69 (2012).
- Maynard, JA, Petersson, KP, Wilson, DH, Adams, EJ, Blondelle, SJ, Boulanger, MJ, Wilson, D., and Garcia, KC. Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity. Immunity, 22: 81-92 (2005).
- Maynard, JA, Maassen, CBM, Leppla, SH, Brasky, K, Patterson, JL, Iverson, BL, and Georgiou, G. Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity. Nature Biotechnology, 20(6): 597-602 (2002).